Triclosan exposure induced disturbance of gut microbiota and exaggerated experimental colitis in mice.

ABSTRACT:

Background

Triclosan, an antimicrobial agent in personal care products, could be absorbed into the human body through the digestive tract. This animal experiment aimed to clarify the effects of triclosan exposure on the microbiome and intestinal immune functions in healthy and ulcerative colitis models.

Methods

Balb/c mice were maintained on an AIN-93G diet containing 80ppm triclosan dissolved in polyethylene as vehicle or vehicle alone for 1 week or 4 weeks. In the end, the mice were sacrificed, blood samples and colon tissues were collected for analysis of inflammation, and fecal samples were collected for 16 S rRNA sequencing of gut microbiota. To establish ulcerative colitis mice model, at the beginning of the 4th week, mice maintained on the diet with or without triclos

SUBMITTER: Liu J 

PROVIDER: S-EPMC9675201 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature