Exploring the pharmacological mechanism of Shengjing capsule on male infertility by a network pharmacology approach.

ABSTRACT:

Background

Shengjing capsule (SJC) is a traditional Chinese medicine (TCM) and has gained widespread clinical application for the treatment of male infertility (MI). However, the pharmacological mechanism of SJC against MI remains vague to date.

Method

The active ingredients of SJC and their targets were identified from the database, and MI-related genes were retrieved from several databases. Protein-protein interaction (PPI) data were obtained to construct the PPI networks. The candidate targets of SJC against MI were identified through topological analysis of the PPI network. Functional enrichment analysis of candidate targets was performed, and the key target genes were identified from the gene-pathway network.

Results

We identified 154 active ingredients and 314 h

SUBMITTER: Wang M 

PROVIDER: S-EPMC9675225 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature