Estrogen Protects Cardiac Function and Energy Metabolism in Dilated Cardiomyopathy Induced by Loss of Cardiac IRS1 and IRS2.

ABSTRACT:

Background

Type 2 diabetes (T2D) is a high-risk factor for incident of cardiovascular diseases. Women at young ages show a reduced incidence of both T2D and cardiovascular diseases compared with men, but these disparities disappear in postmenopausal women versus age-matched men. Thus, ovaries and ovarian hormones, such as estrogen, are expected to protect from T2D and cardiovascular diseases. In this study, we aimed to investigate the role of ovaries and ovarian hormone estrogen in cardiac function and energy metabolism using the cardiac IRS (insulin receptor substrate) 1 and IRS2 double genes knockout mice that mimic cardiac insulin resistance.

Methods

Control and heart-specific IRS1/2 double genes knockout mice were treated with placebo or 17β-estradiol (E₂) pel

SUBMITTER: Yan H 

PROVIDER: S-EPMC9675316 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature