Urinary phthalate metabolite concentrations are negatively associated with follicular fluid anti-mullerian hormone concentrations in women undergoing fertility treatment.

ABSTRACT: Exposure to phthalates, endocrine-disrupting chemicals commonly used as plasticizers and in consumer products, has been associated with infertility and premature ovarian failure. Our objective was to investigate whether urinary phthalate metabolite concentrations were associated with pre-ovulatory follicular fluid (FF) anti-müllerian hormone (AMH) concentrations in women undergoing fertility treatment. This cross-sectional analysis included 138 women with urinary phthalate data available in the Environment and Reproductive Health (EARTH) Study (2010-2016) in whom FF AMH concentrations were quantified using a sandwich enzyme-linked immunosorbent assay (ELISA). We also quantified 8 phthalate metabolite concentrations using tandem mass spectrometry in 1-2 urine samples per cycle (total 331 ur

SUBMITTER: Sacha CR 

PROVIDER: S-EPMC9675335 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature