DNA repair pathways as a novel therapeutic strategy in esophageal cancer: A review study.
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ABSTRACT:
SUBMITTER: Kheyrandish MR
PROVIDER: S-EPMC9675361 | biostudies-literature | 2022 Nov
REPOSITORIES: biostudies-literature
Publications
DNA repair pathways as a novel therapeutic strategy in esophageal cancer: A review study.
Kheyrandish Mohammad Reza MR Mir Seyed Mostafa SM Sheikh Arabi Mehdi M
Cancer reports (Hoboken, N.J.) 20220922 11
Esophageal cancer (EC) is a common malignancy with a poor prognosis worldwide. There are two core pathways that repair double-strand breaks, homologous recombination (HR) and non-homologous end joining (NHEJ) and numerous proteins are recognized that affect the occurrence of HR and NHEJ. Altered DNA damage response (DDR) pathways are associated with cancer susceptibility and affect therapeutic response and resistance in cancers. DDR pathway alterations in EC are still poorly understood. Therefor ...[more]
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