The whole-cell pertussis vaccine imposes a broad effector B cell response in mouse heterologous prime-boost settings.

ABSTRACT: ÍSince the introduction of new generation pertussis vaccines, resurgence of pertussis has been observed in many developed countries. Former whole-cell pertussis (wP) vaccines are able to protect against disease and transmission but have been replaced in several industrialized countries because of their reactogenicity and adverse effects. Current acellular pertussis (aP) vaccines, made of purified proteins of Bordetella pertussis, are efficient at preventing disease but fail to induce long-term protection from infection. While the systemic and mucosal T cell immunity induced by the 2 types of vaccines has been well described, much less is known concerning B cell responses. Taking advantage of an inducible activation-induced cytidine deaminase fate-mapping mouse model, we compared effector a

SUBMITTER: Valeri V 

PROVIDER: S-EPMC9675447 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature