Bioinformatic analysis identifies potential key genes in the pathogenesis of age-related macular degeneration.

ABSTRACT:

Purpose

Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in older individuals. More studies focused on screening the genes, which may be correlated with the development of AMD. With advances in various technologies like multiple microarray datasets, researchers could identify differentially expressed genes (DEGs) more accurately. Exploring abnormal gene expression in disease status can help to understand pathophysiological changes in complex diseases. This study aims to identify the key genes and upstream regulators in AMD and reveal factors, especially genetic association, and the prognosis of the development of this disease.

Methods

Data from expression profile GSE125564 and profile GSE29801 were obtained from the Gene Expression Omnibu

SUBMITTER: Wang Z 

PROVIDER: S-EPMC9675553 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature