ADAM17-mediated EGFR ligand shedding directs macrophage-promoted cancer cell invasion.

ABSTRACT: Macrophages in the tumor microenvironment have a substantial impact on tumor progression. Depending on the signaling environment in the tumor, macrophages can either support or constrain tumor progression. It is therefore of therapeutic interest to identify the tumor-derived factors that control macrophage education. With this aim, we correlated the expression of A Disintegrin and Metalloproteinase (ADAM) proteases, which are key mediators of cell-cell signaling, to the expression of protumorigenic macrophage markers in human cancer cohorts. We identified ADAM17, a sheddase upregulated in many cancer types, as a protein of interest. Depletion of ADAM17 in cancer cell lines reduced the expression of several protumorigenic markers in neighboring macrophages in vitro as well as in mouse model

SUBMITTER: Gnosa SP 

PROVIDER: S-EPMC9675555 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature