Validation and Meaningful Change Thresholds for an Objective Cough Frequency Measurement in Chronic Cough.

ABSTRACT:

Purpose

Objective cough frequency is used to assess efficacy of chronic cough (CC) treatments. The objective of this study was to explore the relationship between objective cough frequency and cough-specific patient-reported outcomes (PROs) and estimate a clinically meaningful change threshold (MCT) for objective cough frequency.

Methods

Data collected in a phase 2b study in participants with refractory or unexplained CC were used to investigate the relationship between 24-h cough frequency (measured using an ambulatory cough monitor) and cough-specific PROs (i.e., cough severity visual analog scale, cough severity diary, Leicester Cough Questionnaire). Convergent validity was assessed using Spearman ρ. An MCT for 24-h cough frequency was estimated using the patient global i

SUBMITTER: Schelfhout J 

PROVIDER: S-EPMC9675653 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature