Impact of Biologic Therapy on the Small Airways Asthma Phenotype.

ABSTRACT: The small airways dysfunction (SAD) asthma phenotype is characterised by narrowing of airways < 2 mm in diameter between generations 8 and 23 of the bronchial tree. Recently, this has become particularly relevant as measurements of small airways using airway oscillometry for example, are strong determinants of asthma control and exacerbations in moderate-to-severe asthma. The small airways can be assessed using spirometry as forced expiratory flow rate between 25 and 75% of forced vital capacity (FEF_25-75) and has been deemed more accurate in detecting small airways dysfunction than forced expiratory volume in 1 s (FEV₁). Oscillometry as the heterogeneity in resistance between 5 and 20 Hz (R5-R20), low frequency reactance at 5 Hz (X5) or area under the reactance curve

SUBMITTER: Chan R 

PROVIDER: S-EPMC9675679 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature