Genetic investigation of the contribution of body composition to anorexia nervosa in an electronic health record setting.

ABSTRACT: Anorexia nervosa (AN) is a psychiatric disorder defined by anthropometric symptoms, such as low body weight, and cognitive-behavioral symptoms, such as restricted eating, fear of weight gain, and distorted body image. Recent studies have identified a genetic association between AN and metabolic/anthropometric factors, including body mass index (BMI). Although the reported associations may be under pleiotropic genetic influences, they may represent independent risk factors for AN. Here we examined the independent contributions of genetic predisposition to low body weight and polygenic risk (PRS) for AN in a clinical population (Vanderbilt University Medical Center biobank, BioVU). We fitted logistic and linear regression models in a retrospective case-control design (123 AN patients, 615 ag

SUBMITTER: Mack T 

PROVIDER: S-EPMC9675730 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature