Increased biventricular hemodynamic forces in precapillary pulmonary hypertension.

ABSTRACT: Precapillary pulmonary hypertension (PH_precap) is a condition with elevated pulmonary vascular pressure and resistance. Patients have a poor prognosis and understanding the underlying pathophysiological mechanisms is crucial to guide and improve treatment. Ventricular hemodynamic forces (HDF) are a potential early marker of cardiac dysfunction, which may improve evaluation of treatment effect. Therefore, we aimed to investigate if HDF differ in patients with PH_precap compared to healthy controls. Patients with PH_precap (n = 20) and age- and sex-matched healthy controls (n = 12) underwent cardiac magnetic resonance imaging including 4D flow. Biventricular HDF were computed in three spatial directions throughout the cardiac cycle using the Navier-Stokes equat

SUBMITTER: Pola K 

PROVIDER: S-EPMC9675772 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature