Organelle-targeted therapies: a comprehensive review on system design for enabling precision oncology.

ABSTRACT: Cancer is a major threat to human health. Among various treatment methods, precision therapy has received significant attention since the inception, due to its ability to efficiently inhibit tumor growth, while curtailing common shortcomings from conventional cancer treatment, leading towards enhanced survival rates. Particularly, organelle-targeted strategies enable precise accumulation of therapeutic agents in organelles, locally triggering organelle-mediated cell death signals which can greatly reduce the therapeutic threshold dosage and minimize side-effects. In this review, we comprehensively discuss history and recent advances in targeted therapies on organelles, specifically including nucleus, mitochondria, lysosomes and endoplasmic reticulum, while focusing on organelle structures,

SUBMITTER: Yang J 

PROVIDER: S-EPMC9675787 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature