Paternal nicotine taking elicits heritable sex-specific phenotypes that are mediated by hippocampal Satb2.

ABSTRACT: Nicotine intake, whether through tobacco smoking or e-cigarettes, remains a global health concern. An emerging preclinical literature indicates that parental nicotine exposure produces behavioral, physiological, and molecular changes in subsequent generations. However, the heritable effects of voluntary parental nicotine taking are unknown. Here, we show increased acquisition of nicotine taking in male and female offspring of sires that self-administered nicotine. In contrast, self-administration of sucrose and cocaine were unaltered in male and female offspring suggesting that the intergenerational effects of paternal nicotine taking may be reinforcer specific. Further characterization revealed memory deficits and increased anxiety-like behaviors in drug-naive male, but not female, offspr

SUBMITTER: Maurer JJ 

PROVIDER: S-EPMC9675874 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature