Artificial Neural Network Modeling of Nanostructured Lipid Carriers Containing 5-O-Caffeoylquinic Acid-Rich Cratoxylum formosum Leaf Extract for Skin Application.

ABSTRACT: Purpose: To investigate the in vitro anti-skin-aging properties of Cratoxylum formosum extract and encapsulate this plant extract in nanostructured lipid carriers (CFE-NLCs) for dermal application. Methods: The biological properties of the plant extract, including enhanced procollagen type I synthesis and anti-matrix metalloproteinase activity, were evaluated to assess its cosmetic benefits. An artificial neural network (ANN) coupled with K-fold cross-validation was applied to investigate the effects of the formulants and optimize the CFE-NLCs. The physicochemical properties, percutaneous absorption, and irritation potential of the CFE-NLCs were analyzed. Results: Liquid chromatography-mass spectrometry analysis revealed that CFE contained 5

SUBMITTER: Navabhatra A 

PROVIDER: S-EPMC9675925 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature