Ontology highlight
ABSTRACT:
SUBMITTER: Choudhary MC
PROVIDER: S-EPMC9675946 | biostudies-literature | 2022 Nov
REPOSITORIES: biostudies-literature
Choudhary Manish C MC Chew Kara W KW Deo Rinki R Flynn James P JP Regan James J Crain Charles R CR Moser Carlee C Hughes Michael D MD Ritz Justin J Ribeiro Ruy M RM Ke Ruian R Dragavon Joan A JA Javan Arzhang Cyrus AC Nirula Ajay A Klekotka Paul P Greninger Alexander L AL Fletcher Courtney V CV Daar Eric S ES Wohl David A DA Eron Joseph J JJ Currier Judith S JS Parikh Urvi M UM Sieg Scott F SF Perelson Alan S AS Coombs Robert W RW Smith Davey M DM Li Jonathan Z JZ
Nature microbiology 20221026 11
SARS-CoV-2 mutations that cause resistance to monoclonal antibody (mAb) therapy have been reported. However, it remains unclear whether in vivo emergence of SARS-CoV-2 resistance mutations alters viral replication dynamics or therapeutic efficacy in the immune-competent population. As part of the ACTIV-2/A5401 randomized clinical trial (NCT04518410), non-hospitalized participants with symptomatic SARS-CoV-2 infection were given bamlanivimab (700 mg or 7,000 mg) or placebo treatment. Here¸ we rep ...[more]