Angiogenin Released from ABCB5⁺ Stromal Precursors Improves Healing of Diabetic Wounds by Promoting Angiogenesis.

ABSTRACT: Severe angiopathy is a major driver for diabetes-associated secondary complications. Knowledge on the underlying mechanisms essential for advanced therapies to attenuate these pathologies is limited. Injection of ABCB5⁺ stromal precursors at the edge of nonhealing diabetic wounds in a murine db/db model, closely mirroring human type 2 diabetes, profoundly accelerates wound closure. Strikingly, enhanced angiogenesis was substantially enforced by the release of the ribonuclease angiogenin from ABCB5⁺ stromal precursors. This compensates for the profoundly reduced angiogenin expression in nontreated murine chronic diabetic wounds. Silencing of angiogenin in ABCB5⁺ stromal precursors before injection significantly reduced angiogenesis and delayed wound closure

SUBMITTER: Singh K 

PROVIDER: S-EPMC9676024 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature