Emerging patterns of fluoroquinolone resistance in Campylobacter jejuni in the UK [1998-2018].

ABSTRACT: Campylobacter jejuni (C.jejuni) is the most common causative agent of bacterial food poisoning worldwide and is known to be genetically highly diverse. C. jejuni is increasingly resistant to fluoroquinolone antibiotics, but very few studies have investigated variant-specific patterns of resistance across time. Here we use statistical modelling and clustering techniques to investigate patterns of fluoroquinolone resistance amongst 10,359 UK isolates from human disease sampled over 20 years. We observed six distinct patterns of fluoroquinolone sensitivity/resistance in C. jejuni across time, grouping by clonal complex (CC). Some CCs were fully resistant, some shifted from susceptible to resistant following a sigmoidal shape, and some remained susceptible over time

SUBMITTER: Veltcheva D 

PROVIDER: S-EPMC9676030 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature