Exploring the mobilome and resistome of Enterococcus faecium in a One Health context across two continents.

ABSTRACT: Enterococcus faecium is a ubiquitous opportunistic pathogen that is exhibiting increasing levels of antimicrobial resistance (AMR). Many of the genes that confer resistance and pathogenic functions are localized on mobile genetic elements (MGEs), which facilitate their transfer between lineages. Here, features including resistance determinants, virulence factors and MGEs were profiled in a set of 1273 E. faecium genomes from two disparate geographic locations (in the UK and Canada) from a range of agricultural, clinical and associated habitats. Neither lineages of E. faecium, type A and B, nor MGEs are constrained by geographic proximity, but our results show evidence of a strong association of many profiled genes and MGEs with habitat. Many features were associated wi

SUBMITTER: Sanderson H 

PROVIDER: S-EPMC9676038 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature