The histone code of the fungal genus Aspergillus uncovered by evolutionary and proteomic analyses.

ABSTRACT: Chemical modifications of DNA and histone proteins impact the organization of chromatin within the nucleus. Changes in these modifications, catalysed by different chromatin-modifying enzymes, influence chromatin organization, which in turn is thought to impact the spatial and temporal regulation of gene expression. While combinations of different histone modifications, the histone code, have been studied in several model species, we know very little about histone modifications in the fungal genus Aspergillus, whose members are generally well studied due to their importance as models in cell and molecular biology as well as their medical and biotechnological relevance. Here, we used phylogenetic analyses in 94 Aspergilli as well as other fungi to uncover the occurrence and evolutiona

SUBMITTER: Zhang X 

PROVIDER: S-EPMC9676040 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature