Endemic erythromycin resistant <i>Corynebacterium diphtheriae</i> in Vietnam in the 1990s.

ABSTRACT: Diphtheria is a potentially fatal respiratory disease caused by toxigenic forms of the Gram-positive bacterium Corynebacterium diphtheriae. Despite the availability of treatments (antitoxin and antimicrobials) and effective vaccines, the disease still occurs sporadically in low-income countries and in higher income where use of diphtheria vaccine is inconsistent. Diphtheria was highly endemic in Vietnam in the 1990s; here, we aimed to provide some historical context to the circulation of erythromycin resistant organisms in Vietnam during this period. After recovering 54 C. diphtheriae isolated from clinical cases of diphtheria in Ho Chi Minh City between 1992 and 1998 we conducted whole genome sequencing and analysis. Our data outlined substantial genetic diversity amo

SUBMITTER: Nguyen Thi Nguyen T 

PROVIDER: S-EPMC9676054 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature