A Unified Approach to Decarboxylative Halogenation of (Hetero)aryl Carboxylic Acids.

ABSTRACT: Aryl halides are a fundamental motif in synthetic chemistry, playing a critical role in metal-mediated cross-coupling reactions and serving as important scaffolds in drug discovery. Although thermal decarboxylative functionalization of aryl carboxylic acids has been extensively explored, the scope of existing halodecarboxylation methods remains limited, and there currently exists no unified strategy that provides access to any type of aryl halide from an aryl carboxylic acid precursor. Herein, we report a general catalytic method for direct decarboxylative halogenation of (hetero)aryl carboxylic acids via ligand-to-metal charge transfer. This strategy accommodates an exceptionally broad scope of substrates. We leverage an aryl radical intermediate toward divergent functionalization pathway

SUBMITTER: Chen TQ 

PROVIDER: S-EPMC9676088 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature