Comparing pre-operative versus post-operative single and multi-fraction stereotactic radiotherapy for patients with resectable brain metastases.

ABSTRACT:

Background

The standard treatment for patients with large brain metastases and limited intracranial disease is surgical resection and post-operative stereotactic radiosurgery (SRS). However, post-operative SRS still has elevated rates of local failure (LF) and is complicated by radiation necrosis (RN), and meningeal disease (MD). Pre-operative SRS may reduce the risk of RN and MD, while fractionated therapy may improve local control through delivering a higher biological effective dose. We hypothesize that pre-operative fractionated stereotactic radiation therapy (FSRT) will have less toxicity compared to patients who receive post-operative SRS or FSRT.

Methods

A multi-institutional analysis was conducted and included patients who had surgical resection and stereotactic radi

SUBMITTER: Perlow HK 

PROVIDER: S-EPMC9676204 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature