Human papillomavirus infection can alter the level of tumour stemness and T cell infiltration in patients with head and neck squamous cell carcinoma.

ABSTRACT: Head and neck squamous cell carcinoma (HNSCC) usually has a poor prognosis and is associated with a high mortality rate. Its etiology is mainly the result from long-term exposure to either alcohol, tobacco or human papillomavirus (HPV) infection or a combination of these insults. However, HNSCC patients with HPV have been found to show a survival advantage over those without the virus, but the mechanism that confers this advantage is unclear. Due to the large number of HPV-independent HNSCC cases, there is a possibility that the difference in prognosis between HPV-positive (HPV⁺) and negative (HPV^-) patients is due to different carcinogens. To clarify this, we used scRNA data and viral tracking methods in order to identify HPV⁺ and HPV^- cells in

SUBMITTER: Meng L 

PROVIDER: S-EPMC9676257 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature