High-level of intratumoral GITR+ CD4 T cells associate with poor prognosis in gastric cancer.
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ABSTRACT:
SUBMITTER: Ke S
PROVIDER: S-EPMC9676631 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
Publications
High-level of intratumoral GITR+ CD4 T cells associate with poor prognosis in gastric cancer.
Ke Shouyu S Xie Feng F Guo Yixian Y Chen Jieqiong J Wang Zeyu Z Yu Yimeng Y Geng Haigang H Xu Danhua D Liu Xu X Xia Xiang X Yu Fengrong F Zhu Chunchao C Zhang Zizhen Z Zhao Gang G Li Bin B Zhao Wenyi W
iScience 20221107 12
Immunotherapy targeting glucocorticoid-induced TNFR-related protein (GITR) exhibited strong anti-tumor capacity in mouse model but poor efficacy in clinical trials. This may be attributed to the different GITR expression mode between human and mouse. In this study, we analyzed single-cell RNA sequencing (scRNA-seq) data of human gastric cancer (GC) and used flow to explore the GITR expression across T cell subsets and tissue types in GC patients. We revealed that GITR+ CD4 T cells, including reg ...[more]
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