PERM1 regulates energy metabolism in the heart via ERRα/PGC-1α axis.

ABSTRACT:

Aims

PERM1 is a striated muscle-specific regulator of mitochondrial bioenergetics. We previously demonstrated that PERM1 is downregulated in the failing heart and that PERM1 positively regulates metabolic genes known as targets of the transcription factor ERRα and its coactivator PGC-1α in cultured cardiomyocytes. The aims of this study were to determine the effect of loss of PERM1 on cardiac function and energetics using newly generated Perm1-knockout (Perm1 ^-/-) mice and to investigate the molecular mechanisms of its transcriptional control.

Methods and results

Echocardiography showed that ejection fraction and fractional shortening were lower in Perm1 ^-/- mice than in wild-type mice (both p < 0.05), and the phosphocreatine

SUBMITTER: Oka SI 

PROVIDER: S-EPMC9676655 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature