Prognostic markers for the clinical course in the blood of patients with SARS-CoV-2 infection.

ABSTRACT:

Background

The presentation of peptides and the subsequent immune response depend on the MHC characteristics and influence the specificity of the immune response. Several studies have found an association between HLA variants and differential COVID-19 outcomes and have shown that HLA genotypes are associated with differential immune responses against SARS-CoV-2, particularly in severely ill patients. Information, whether HLA haplotypes are associated with the severity or length of the disease in moderately diseased individuals is absent.

Methods

Next-generation sequencing-based HLA typing was performed in 303 female and 231 male non-hospitalized North Rhine Westphalian patients infected with SARS-CoV2 during the first and second wave. For HLA-Class I, we obtained results fro

SUBMITTER: Fischer JC 

PROVIDER: S-EPMC9676819 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature