Immune profiling identifies CD8⁺ T-cell subset signatures as prognostic markers for recurrence in papillary thyroid cancer.

ABSTRACT:

Background

Thyroid tissue has a special immune microenvironment that is not well characterized. Whether immune cells have a prognostic value in the recurrence of papillary thyroid cancer (PTC) needs further investigation.

Methods

Multinodular non-toxic goiter (MNG) was taken as normal tissue for the difficulty in obtaining completely normal thyroid tissue (normal thyroid function, no thyroiditis, and no nodules). We compared the composition of mononuclear cells (MNCs) in peripheral blood and thyroid tissues from MNG and PTC patients by high-dimensional flow cytometry profiling and verified the results by multiplex immunohistochemistry. The recurrence rates of PTC patients with different CD8⁺T cell subset signatures were compared using TCGA database.

Results

SUBMITTER: Chen Z 

PROVIDER: S-EPMC9676940 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature