Genetic predisposition to neurodegenerative diseases and risk of stroke: A Mendelian randomization study.

ABSTRACT:

Background

Traditional epidemiological studies suggested that Neurodegenerative diseases (ND) might correlate with stroke. We intend to explore whether the two most common neurodegenerative diseases [Alzheimer's disease (AD) and Parkinson's disease (PD)] are causally associated with stroke and its subtypes.

Methods

Two-sample Mendelian Randomization (MR) method was used to explore the causal relationships. Candidate genetic instrumental variables (IVs) for AD and PD were collected from the genome-wide association studies (GWAS) in European populations. The inverse-variance weighted (IVW) method was the primary method of MR analysis, and the weighted median method was supplementary. In addition, the MR-Egger method and the MR-PRESSO test were used as well.

Results

We f

SUBMITTER: Li F 

PROVIDER: S-EPMC9676950 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature