Development and Degeneration of Retinal Ganglion Cell Axons in Xenopus tropicalis.

ABSTRACT: Neurons make long-distance connections via their axons, and the accuracy and stability of these connections are crucial for brain function. Research using various animal models showed that the molecular and cellular mechanisms underlying the assembly and maintenance of neuronal circuitry are highly conserved in vertebrates. Therefore, to gain a deeper understanding of brain development and maintenance, an efficient vertebrate model is required, where the axons of a defined neuronal cell type can be genetically manipulated and selectively visualized in vivo. Placental mammals pose an experimental challenge, as time-consuming breeding of genetically modified animals is required due to their in utero development. Xenopus laevis, the most commonly used amphibian model, off

SUBMITTER: Choi B 

PROVIDER: S-EPMC9676988 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature