Mapping brain endophenotypes associated with idiopathic pulmonary fibrosis genetic risk.

ABSTRACT:

Background

Idiopathic pulmonary fibrosis (IPF) is a serious disease of the lung parenchyma. It has a known polygenetic risk, with at least seventeen regions of the genome implicated to date. Growing evidence suggests linked multimorbidity of IPF with neurodegenerative or affective disorders. However, no study so far has explicitly explored links between IPF, associated genetic risk profiles, and specific brain features.

Methods

We exploited imaging and genetic data from more than 32,000 participants available through the UK Biobank population-level resource to explore links between IPF genetic risk and imaging-derived brain endophenotypes. We performed a brain-wide imaging-genetics association study between the presence of 17 known IPF risk variants and 1248 multi-modal imag

SUBMITTER: Mohammadi-Nejad AR 

PROVIDER: S-EPMC9677133 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature