Neurocognitive Performance in Adults Treated With Radiation for a Primary Brain Tumor.

ABSTRACT:

Purpose

The contributory effects of radiation dose to different brain regions on neurocognitive performance after radiation therapy (RT) for primary brain tumors is not well known.

Methods and materials

In this retrospective cohort study, 30 patients with brain tumors treated with photon RT were identified, and radiation dosimetric parameters across brain regions were calculated. All patients had longitudinal neurocognitive evaluations at baseline and after treatment. Generalized estimating equations were used to model each neurocognitive endpoint over time in a multivariable analysis, while adjusted for multiple comparisons of brain regions.

Results

Median follow-up from RT to last assessment was 4.1 years. Fewer years of formal education and older age at the time of

SUBMITTER: Tsang DS 

PROVIDER: S-EPMC9677214 | biostudies-literature | 2022 Nov-Dec

REPOSITORIES: biostudies-literature