Skin Biopsy as a Novel Diagnostic Aid in Immune-Mediated Neuropathies.

ABSTRACT: Immune-mediated neuropathies are a heterogenous group of inflammatory peripheral nerve disorders. They can be classified according to the domain where the autoimmune process begins: the internode, paranode, or node. However, conventional diagnostic tools, electrodiagnosis (EDX), and autoantibody testing do not fully address this issue. In this institutional cohort study, we investigated the value of dermal myelinated fiber analysis for target domain-based classification. Twenty-seven consecutive patients with immune-mediated neuropathies underwent skin biopsies. The sections were stained with antibodies representative of myelinated fiber domains and were scanned using a confocal microscope. Clinical and pathological features of each patient were reviewed comprehensively. Quantitative morph

SUBMITTER: Min YG 

PROVIDER: S-EPMC9677240 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature