Combined proton radiography and irradiation for high-precision preclinical studies in small animals.

ABSTRACT:

Background and purpose

Proton therapy has become a popular treatment modality in the field of radiooncology due to higher spatial dose conformity compared to conventional radiotherapy, which holds the potential to spare normal tissue. Nevertheless, unresolved research questions, such as the much debated relative biological effectiveness (RBE) of protons, call for preclinical research, especially regarding in vivo studies. To mimic clinical workflows, high-precision small animal irradiation setups with image-guidance are needed.

Material and methods

A preclinical experimental setup for small animal brain irradiation using proton radiographies was established to perform planning, repositioning, and irradiation of mice. The image quality of proton radiographies was optim

SUBMITTER: Schneider M 

PROVIDER: S-EPMC9677333 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature