GLH-1/Vasa represses neuropeptide expression and drives spermiogenesis in the C. elegans germline.

ABSTRACT: Germ granules harbor processes that maintain germline integrity and germline stem cell capacity. Depleting core germ granule components in C. elegans leads to the reprogramming of germ cells, causing them to express markers of somatic differentiation in day-two adults. Somatic reprogramming is associated with complete sterility at this stage. The resulting germ cell atrophy and other pleiotropic defects complicate our understanding of the initiation of reprogramming and how processes within germ granules safeguard the totipotency and immortal potential of germline stem cells. To better understand the initial events of somatic reprogramming, we examined total mRNA (transcriptome) and polysome-associated mRNA (translatome) changes in a precision full-length deletion of glh-1, which encodes a

SUBMITTER: Rochester JD 

PROVIDER: S-EPMC9677334 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature