Blood-brain barrier permeability to enrofloxacin in Pengze crucian carp (Carassius auratus var. Pengze).

ABSTRACT:

Background

Enrofloxacin (ENR) is a kind of quinolone antibiotic that is most widely used antimicrobials in veterinary practice, and possesses both a broad spectrum antimicrobial activity against a range of bacteria and adverse effects towards plants and animals.

Objectives

This study was conducted to explore the permeability of blood-brain barrier (BBB) to ENR and brain injury based on crucian carp orally administrated with high dose of ENR.

Methods

Juvenile Pengze crucian carp were treated with half lethal dose (LD₅₀ ) or safe dose (SD₅₀ ) of ENR. BBB permeability was determined by evaluating ENR contents detected by HPLC and evens blue contents estimated by confocal laser scanning microscope. Brain damage was evaluated by measuring protein and

SUBMITTER: Zhang F 

PROVIDER: S-EPMC9677365 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature