Preclinical safety of a bionic tiger bone capsule in Sprague-Dawley rats and beagle dogs.

ABSTRACT:

Background

Jintiange capsule is composed of bionic tiger bone powder and has similar ingredients to natural tiger bone.

Objective

To characterize the subacute toxicities of Jintiange capsule in rats and beagle dogs for preclinical safety assessment.

Methods

Suspensions of Jintiange capsule were given via gastric lavage over a 26-week period at low (500 mg/kg), mid (1500 mg/kg) and high doses (4000 mg/kg) in SD rats. Beagles were given by gastric lavage of suspensions of Jintiange capsule once daily for 6 days per week for 39 weeks at low (300 mg/kg), mid (900 mg/kg) or high dose (2000 mg/kg).

Results

Repeated gastric lavages of suspensions of Jintiange capsule at doses from 500 to 4000 mg/kg over 26 weeks caused no significant toxicity (No Observed Adverse Effe

SUBMITTER: Wan SF 

PROVIDER: S-EPMC9677368 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature