Modelling the dynamics of infection, waning of immunity and re-infection with the Omicron variant of SARS-CoV-2 in Aotearoa New Zealand.

ABSTRACT: Aotearoa New Zealand experienced a wave of the Omicron variant of SARS-CoV-2 in 2022 with around 200 confirmed cases per 1000 people between January and May. Waning of infection-derived immunity means people become increasingly susceptible to re-infection with SARS-CoV-2 over time. We investigated a model that included waning of vaccine-derived and infection-derived immunity under scenarios representing different levels of behavioural change relative to the first Omicron wave. Because the durability of infection-derived immunity is a key uncertainty in epidemiological models, we investigated outcomes under different assumptions about the speed of waning. The model was used to provide scenarios to the New Zealand Government, helping to inform policy response and healthcare system preparedne

SUBMITTER: Vattiatio G 

PROVIDER: S-EPMC9677563 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature