SLIT2 promoter hypermethylation predicts disease progression in chronic myeloid leukemia.

ABSTRACT:

Background

Aberrant DNA methylation plays a crucial role in the progression of myeloid neoplasms. Previously, our literature reported that slit guidance ligand 2 (SLIT2) promoter methylation was associated with disease progression and indicated a poor prognosis in patients with myelodysplastic syndrome. Herein, we further investigated the clinical implications and role of SLIT2 promoter methylation in patients with chronic myeloid leukemia (CML).

Methods

The level of SLIT2 promoter methylation was determined in 104 CML patients, and its clinical significance was analyzed. Moreover, demethylation studies were performed in K562 cells to determine the epigenetic mechanism by which SLIT2 promoter methylation is regulated in CML.

Results

The level of SLIT2 promoter methyla

SUBMITTER: Wu DL 

PROVIDER: S-EPMC9677675 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature