FGF12 is a novel component of the nucleolar NOLC1/TCOF1 ribosome biogenesis complex.

ABSTRACT: Among the FGF proteins, the least characterized superfamily is the group of fibroblast growth factor homologous factors (FHFs). To date, the main role of FHFs has been primarily seen in the modulation of voltage-gated ion channels, but a full picture of the function of FHFs inside the cell is far from complete. In the present study, we focused on identifying novel FGF12 binding partners to indicate its intracellular functions. Among the identified proteins, a significant number were nuclear proteins, especially RNA-binding proteins involved in translational processes, such as ribosomal processing and modification. We have demonstrated that FGF12 is localized to the nucleolus, where it interacts with NOLC1 and TCOF1, proteins involved in the assembly of functional ribosomes. Interactions wi

SUBMITTER: Sochacka M 

PROVIDER: S-EPMC9677703 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature