New Insights into the Pathogenesis and Treatment Strategies in IgA Nephropathy.

ABSTRACT:

Background

Immunoglobulin A nephropathy (IgAN) is the most common form of primary glomerulonephritis worldwide. It is defined by mesangial IgA deposition, with consequent mesangial cell proliferation, inflammation, and tubulointerstitial fibrosis.

Summary

Approximately 30% of affected patients will progress to end-stage kidney disease within 20 years of diagnosis. Currently, there is no disease-specific treatment available and management recommendations are, in general, limited to optimization of lifestyle measures and use of renin-angiotensin-aldosterone system blockers. More recently, advances in the understanding of the pathogenesis of IgAN have informed the development of novel therapeutic strategies that are now being tested in clinical trials. These have focused on dif

SUBMITTER: Scionti K 

PROVIDER: S-EPMC9677740 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature