Circulating Chlamydia Trachomatis Antigens in Subjects With Alzheimer's Disease.

ABSTRACT:

Background/aim

Chlamydia pneumoniae (C. pneumoniae) is implicated in the pathogenesis of Alzheimer's disease (AD). Chlamydial elementary and reticulate bodies have been identified in tissues from afflicted AD brain regions by electron and immunoelectron microscopy, whereas similar tests of non-AD brains were negative for the bacterium. Studies in mice have shown that C. pneumoniae can rapidly penetrate the central nervous system by entering glia and causing beta amyloid deposition via the nerves between the nasal cavity and the brain, which serve as invasion pathways.

Materials and methods

We used data from the UK Biobank (UKBB) to assess the relationship of chlamydia and AD. Circulating C. pneumoniae antigen measurements were not available, but UKBB data field 23037 held me

SUBMITTER: Lehrer S 

PROVIDER: S-EPMC9677800 | biostudies-literature | 2022 Nov-Dec

REPOSITORIES: biostudies-literature