Improved diffusion parameter estimation by incorporating T₂ relaxation properties into the DKI-FWE model.

ABSTRACT: The free water elimination (FWE) model and its kurtosis variant (DKI-FWE) can separate tissue and free water signal contributions, thus providing tissue-specific diffusional information. However, a downside of these models is that the associated parameter estimation problem is ill-conditioned, necessitating the use of advanced estimation techniques that can potentially bias the parameter estimates. In this work, we propose the T₂-DKI-FWE model that exploits the T₂ relaxation properties of both compartments, thereby better conditioning the parameter estimation problem and providing, at the same time, an additional potential biomarker (the T₂ of tissue). In our approach, the T₂ of tissue is estimated as an unknown parameter, whereas the T₂

SUBMITTER: Anania V 

PROVIDER: S-EPMC9677810 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature