Significance of urine complement proteins in monitoring lupus activity.

ABSTRACT:

Objectives

Complement activation is a critical feature in the development of systemic lupus erythematosus (SLE). Whether there are changes of complement components in the urine of SLE has not been reported. The aim of the study was to evaluate the complement-related proteins in the urine of SLE, verify differentially expressed proteins(DEPs) in the active phase of SLE, further explore their clinical application value.

Methods

First, we used bioinformatics and functional enrichment to screen and identify the urine protein profile of SLE patients. Then, analyzed and verified the proteins related to the complement pathway by western-blot and Parallel Reaction Monitoring (PRM) technology. Further evaluated the relationship between urinary DEPs related to complement pathway and d

SUBMITTER: Zhao J 

PROVIDER: S-EPMC9677877 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature