Genome-wide analyses identify novel risk loci for cluster headache in Han Chinese residing in Taiwan.

ABSTRACT:

Background

Cluster headache is a highly debilitating neurological disorder with considerable inter-ethnic differences. Genome-wide association studies (GWAS) recently identified replicable genomic loci for cluster headache in Europeans, but the genetic underpinnings for cluster headache in Asians remain unclear. The objective of this study is to investigate the genetic architecture and susceptibility loci of cluster headache in Han Chinese resided in Taiwan.

Methods

We conducted a two-stage genome-wide association study in a Taiwanese cohort enrolled from 2007 through 2022 to identify the genetic variants associated with cluster headache. Diagnosis of cluster headache was retrospectively ascertained with the criteria of International Classification of Headache Disorders, thi

SUBMITTER: Chen SP 

PROVIDER: S-EPMC9677903 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature