Large-scale correlation analysis of deep venous thrombosis and gut microbiota.

ABSTRACT:

Objective

Although previous studies have shown that gut microbiota may be involved in the occurrence of deep venous thrombosis (DVT), the specific link between the two remains unclear. The present study aimed to explore this question from a genetic perspective.

Materials and methods

Genome-wide association study (GWAS) summary data of DVT were obtained from the UK Biobank (N = 9,059). GWAS summary data of the gut microbiota were obtained from the Flemish Gut Flora Project (N = 2,223) and two German cohorts (FoCus, N = 950; PopGen, N = 717). All the participants were of European ancestry. Linkage disequilibrium score (LDSC) regression has great potential for analyzing the heritability of disease or character traits. LDSC regression was used to anal

SUBMITTER: Yang M 

PROVIDER: S-EPMC9677955 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature