Germline mutations in penetrant cancer predisposition genes are rare in men with prostate cancer selecting active surveillance.

ABSTRACT:

Background

Pathogenic germline mutations in several rare penetrant cancer predisposition genes are associated with an increased risk of aggressive prostate cancer (PC). Our objectives were to determine the prevalence of pathogenic germline mutations in men with low-risk PC on active surveillance, and assess whether pathogenic germline mutations associate with grade reclassification or adverse pathology, recurrence, or metastases, in men treated after initial surveillance.

Methods

Men prospectively enrolled in the Canary Prostate Active Surveillance Study (PASS) were retrospectively sampled for the study. Germline DNA was sequenced utilizing a hereditary cancer gene panel. Mutations were classified according to the American College of Clinical Genetics and Genomics' guideline

SUBMITTER: Brady L 

PROVIDER: S-EPMC9678104 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature