Injectable Microporous Annealed Particle Hydrogel Based on Guest-Host-Interlinked Polyethylene Glycol Maleimide Microgels.

ABSTRACT: Microporous annealed particle (MAP) hydrogels have emerged as a versatile biomaterial platform for regenerative medicine. MAP hydrogels have been used for the delivery of cells and organoids but often require annealing post injection by an external source. We engineered an injectable, self-annealing MAP hydrogel with reversible interparticle linkages based on guest-host functionalized polyethylene glycol maleimide (PEG-MAL) microgels. We evaluated the effect of guest-host linkages on different types of microgels fabricated by either batch emulsion or mechanical fragmentation methods. Batch emulsion generated small spherical microgels with controllable 10-100 μm diameters and mechanical fragmentation generated irregular microgels with larger diameters (100-200 μm). Spherical microgels (15 μ

SUBMITTER: Widener AE 

PROVIDER: S-EPMC9678130 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature