Early-Life Factors as Predictors of Age-Associated Deficit Accumulation Across 17 Years From Midlife Into Old Age.

ABSTRACT:

Background

Early-life exposures have been associated with the risk of frailty in old age. We investigated whether early-life exposures predict the level and rate of change in a frailty index (FI) from midlife into old age.

Methods

A linear mixed model analysis was performed using data from 3 measurement occasions over 17 years in participants from the Helsinki Birth Cohort Study (n = 2 000) aged 57-84 years. A 41-item FI was calculated on each occasion. Information on birth size, maternal body mass index (BMI), growth in infancy and childhood, childhood socioeconomic status (SES), and early-life stress (wartime separation from both parents) was obtained from registers and health care records.

Results

At age 57 years the mean FI level was 0.186 and the FI levels increa

SUBMITTER: Haapanen MJ 

PROVIDER: S-EPMC9678199 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature