Unravelling the relationship between amyloid accumulation and brain network function in normal aging and very mild cognitive decline: a longitudinal analysis.

ABSTRACT: Pathological changes in the brain begin accumulating decades before the appearance of cognitive symptoms in Alzheimer's disease. The deposition of amyloid beta proteins and other neurotoxic changes occur, leading to disruption in functional connections between brain networks. Discrete characterization of the changes that take place in preclinical Alzheimer's disease has the potential to help treatment development by targeting the neuropathological mechanisms to prevent cognitive decline and dementia from occurring entirely. Previous research has focused on the cross-sectional differences in the brains of patients with mild cognitive impairment or Alzheimer's disease and healthy controls or has concentrated on the stages immediately preceding cognitive symptoms. The present study emphasizes

SUBMITTER: Moffat G 

PROVIDER: S-EPMC9678202 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature